Author

David Bakker

University of British ColumbiaORCID 0009-0005-5284-6205Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:fluorescence / live-cell microscopy· 1 Research Focus:protein folding & dynamics· 1 Research Focus:synaptic & neural circuits· 1

Frequent Co-Authors

Isaac T. S. LiiD· 2 shared Micah YangiD· 2 shared Adam B. YasunagaiD· 1 shared Dyuti Raghu· 1 shared Ryan Riopel· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

5 top collaborators · 10 mutual co-author links

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2 shared papersBiophysics

Isaac T. S. LiORCID

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2 papers

Recent·Most cited

BiophysicsScience AdvancesPeer-reviewedJun 5, 2026

Massively Parallel Bead-Free Force Spectroscopy with Fluorescence

Adam B. Yasunaga, Ryan Riopel, David Bakker…·Isaac T. S. Li

This paper introduces Tether Force Spectroscopy (TFS), a bead-free single-molecule force spectroscopy method that enables high-throughput, high-resolution measurements of biomolecular conformational dynamics with internally calibrated forces.

2 citations

fluorescence / live-cell microscopyexperimental assay

𝕏 PostBluesky

BiophysicsbioRxivPreprintMar 18, 2026

Mechanical signatures of nucleic acid knot topology

David t. R. Bakker, Micah Yang, Isaac T. S. Li

This study shows that molecular topology in single-stranded DNA leads to distinct mechanical behaviors, providing a way to identify and quantify nucleic acid knots.

DOI 10.64898/2026.03.16.712236

DNA methylationexperimental assay

𝕏 PostBluesky