Author

E. A. Komech

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:statistical model· 4 Research Focus:clustering· 3 Assay:CITE-seq· 2 Assay:scRNA-seq· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

D. M. Chudakov· 4 shared A. A. Minervina· 3 shared I. Z. Mamedov· 3 shared M. V. Pogorelyy· 3 shared T. Mora· 3 shared Y. B. Lebedev· 3 shared A. Franke· 2 shared A. M. Walczak· 2 shared

Activity by Year

2018-2021 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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4 shared papersImmunology

D. M. Chudakov

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4 papers

Recent·Most cited

Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires

A. I. Mikelov, E. I. Alekseeva, E. A. Komech, D. B. Staroverov, M. A. Turchaninova, M. Shugay, D. M. Chudakov, G. A. Bazykin, I. V. Zvyagin

The paper analyzes longitudinal BCR repertoires to show clonal persistence and differentiation into ASCs with positive selection and affinity maturation.

bioRxiv · Dec 30, 2021Immunology

Longitudinal high-throughput TCR repertoire profiling reveals the dynamics of T cell memory formation after mild COVID-19 infection

A. A. Minervina, E. A. Komech, A. Titov, M. Bensouda Koraichi, E. Rosati, I. Z. Mamedov, A. Franke, G. A. Efimov, D. M. Chudakov, T. Mora, A. M. Walczak, Y. B. Lebedev, M. V. Pogorelyy

This study tracks T cell memory formation after mild COVID-19 infection using longitudinal TCR sequencing, showing clonal expansion and memory phenotype acquisition in infected individuals.

bioRxiv · May 18, 2020Immunology

Comprehensive analysis of antiviral adaptive immunity formation and reactivation down to single-cell level

A. A. Minervina, M. V. Pogorelyy, E. A. Komech, V. K. Karnauhov, P. Bacher, E. Rosati, A. Franke, D. M. Chudakov, I. Z. Mamedov, Y. B. Lebedev, T. Mora, A. M. Walczak

The paper tracks T-cell clone dynamics and TCR repertoire changes after primary and secondary yellow fever vaccination using single-cell RNAseq and TCRseq.

bioRxiv · Oct 25, 2019 · PreprintImmunology

Precise tracking of vaccine-responding T-cell clones reveals convergent and personalized response in identical twins

M. V. Pogorelyy, A. A. Minervina, M. Puelma Touzel, A. L. Sycheva, E. A. Komech, E. I. Kovalenko, G. G. Karganova, E. S. Egorov, A. Y. Komkov, D. M. Chudakov, I. Z. Mamedov, T. Mora, A. Walczak, Y. B. Lebedev

The paper develops a statistical framework to detect TCR clone changes in vaccinated twins and finds convergent yet personalized TCR responses.

bioRxiv · Apr 13, 2018Immunology