Author

A. Y. Komkov

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Organism:human· 3 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1 Assay:CITE-seq· 1 Research Focus:clustering· 1

Frequent Co-Authors

D. M. Chudakov· 4 shared I. Z. Mamedov· 3 shared Y. B. Lebedev· 3 shared A. M. Miroshnichenkova· 2 shared A. O. Smirnova· 2 shared A. A. Kesnikov· 1 shared A. A. Minervina· 1 shared A. I. Nekrasova· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersImmunology

D. M. Chudakov

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Author profile →

4 papers

Recent·Most cited

Robust detection of SARS-CoV-2 exposure in population using T-cell repertoire profiling

E. K. Vlasova, A. I. Nekrasova, A. Y. Komkov, M. Izraelson, E. A. Snigir, S. I. Mitrofanov, V. S. Yudin, V. V. Makarov, A. A. Kesnikov, D. Korneeva, A. Pivnyuk, P. V. Shelyakin, I. Z. Mamedov, D. V. Rebrikov, D. M. Chudakov, , M. A. Shugay

The paper develops a classifier for detecting SARS-CoV-2 exposure using T-cell repertoire profiling and machine learning, achieving high accuracy across different protocols.

bioRxiv · Nov 8, 2023 · PreprintImmunology

Non-canonical D1-D2 recombination produces two types of rearrangements and represents a conservative hidden stage of T-cell receptor beta chain generation

A. O. Smirnova, A. M. Miroshnichenkova, L. D. Belyaeva, I. V. Kelmanson, Y. B. Lebedev, I. Z. Mamedov, D. M. Chudakov, A. Y. Komkov

The paper identifies non-canonical D1-D2 recombination in T-cell receptor beta chain generation, revealing two types of rearrangements and their role in memory T-cell function.

bioRxiv · Apr 21, 2023 · PreprintImmunology

The use of non-functional clonotypes as a natural calibrator for quantitative bias correction in adaptive immune receptor repertoire profiling

A. O. Smirnova, A. M. Miroshnichenkova, Y. V. Olshanskaya, M. A. Maschan, Y. B. Lebedev, D. M. Chudakov, I. Mamedov, A. Y. Komkov

The paper introduces a method to correct PCR bias in immune repertoire sequencing by using non-functional clonotypes as a calibrator, improving accuracy across different sequencing approaches.

bioRxiv · Mar 24, 2021Immunology

Precise tracking of vaccine-responding T-cell clones reveals convergent and personalized response in identical twins

M. V. Pogorelyy, A. A. Minervina, M. Puelma Touzel, A. L. Sycheva, E. A. Komech, E. I. Kovalenko, G. G. Karganova, E. S. Egorov, A. Y. Komkov, D. M. Chudakov, I. Z. Mamedov, T. Mora, A. Walczak, Y. B. Lebedev

The paper develops a statistical framework to detect TCR clone changes in vaccinated twins and finds convergent yet personalized TCR responses.

bioRxiv · Apr 13, 2018Immunology