Prosaposin is cleaved into saposins by multiple cathepsins in a progranulin-regulated fashion
M. Hodul, C. Lane-Donovan, E. A. Mambou, Z. Yang, A. W. Kao
This study identifies multiple cathepsins and progranulin that regulate prosaposin cleavage into saposins, which are critical for sphingolipid metabolism.
bioRxiv · Feb 15, 2024Cell Biology