Author

A. W. Kao

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 5 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Organism:human· 3 Assay:proteomics· 2 Organism:C. elegans· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

M. Hodul· 2 shared M. Y. Chin· 2 shared A. L. Nana· 1 shared A. L. Wang· 1 shared A. M. Karydas· 1 shared A. R. Argouarch· 1 shared A. R. Cupo· 1 shared A. R. de Silva· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCell Biology

M. Hodul

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Prosaposin is cleaved into saposins by multiple cathepsins in a progranulin-regulated fashion

M. Hodul, C. Lane-Donovan, E. A. Mambou, Z. Yang, A. W. Kao

This study identifies multiple cathepsins and progranulin that regulate prosaposin cleavage into saposins, which are critical for sphingolipid metabolism.

bioRxiv · Feb 15, 2024Cell Biology

Interaction with the membrane-anchored protein CHIC2 constrains the ubiquitin ligase activity of CHIP

M. D. Callahan, M. Hodul, E. C. Carroll, M. Ravalin, C. M. Nadel, A. R. de Silva, A. R. Cupo, L. E. McDermott, J. C. Nix, R. C. Page, A. W. Kao, J. E. Gestwicki

This study identifies CHIC2 as a chaperone-independent regulator of CHIP, showing it attenuates CHIP's ubiquitin ligase activity and contributes to neurodegeneration in C. elegans.

bioRxiv · Jul 17, 2023 · PreprintBiochemistry

mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes

K. Leng, B. Rooney, F. McCarthy, W. Xia, I. V. L. Rose, S. Bax, M. Y. Chin, S. Fathi, K. A. Herrington, M. Leonetti, A. W. Kao, S. P. J. Fancy, J. E. Elias, M. Kampmann

bioRxiv · Sep 11, 2021 · PreprintCell Biology

A systematic comparison of fibroblasts derived from postmortem human dura mater versus dermal epithelium for neurodegenerative disease modeling

A. R. Argouarch, C. G. Cosme, K. Garcia, C. I. Corrales, A. L. Nana, A. M. Karydas, S. Spina, L. T. Grinberg, B. Miller, H. Goodarzi, W. W. Seeley, A. W. Kao

This study compares fibroblasts from postmortem human dura mater and dermal epithelium, finding significant differences in morphology, growth, marker expression, and chromosomal abnormalities.

bioRxiv · May 17, 2021 · PreprintCell Biology

A genetically encoded, pH-sensitive mTFP1 biosensor for probing lysosomal pH

M. Y. Chin, A. R. Patwardhan, K.-H. Ang, A. L. Wang, C. Alquezar, M. Welch, P. T. Nguyen, M. Grabe, A. V. Molofsky, M. R. Arkin, A. W. Kao

The paper develops a genetically encoded pH biosensor, FIRE-pHLy, for lysosomal pH measurement and demonstrates its use in cellular models.

bioRxiv · Nov 4, 2020 · PreprintCell Biology

Lifespan-increasing drug nordihydroguaiaretic acid inhibits p300 and activates autophagy

T. Tezil, M. Chamoli, C.-P. Ng, R. P. Simon, V. J. Butler, M. Jung, J. Andersen, A. W. Kao, E. Verdin

This study identifies p300 as a target of NDGA, showing it inhibits p300 acetyltransferase activity and activates autophagy, contributing to lifespan extension.

bioRxiv · Jul 30, 2019Cell Biology