Author

E. A. O'Toole

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:metabolomics· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

R. F. O'Shaughnessy· 2 shared A. J. Hughes· 1 shared B. R. Thomas· 1 shared E. Camera· 1 shared E. M. Jones· 1 shared I. Doykov· 1 shared J. A. McGrath· 1 shared K. Mills· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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2 shared papersCell Biology

R. F. O'Shaughnessy

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2 papers

Recent·Most cited

Reduced Filaggrin expression induces dysregulated intracellular signalling in atopic eczema

A. J. Hughes, L. E. Coppock, T. Tachie-Menson, B. R. Thomas, P. Dewan, I. Doykov, K. Mills, E. A. O'Toole, R. F. O'Shaughnessy

This study identifies dysregulated BMP and ERK1/2/AKT signaling in FLG-deficient keratinocytes and AE biopsies, linking FLG loss to altered desmosomal proteins and suggesting a SMAD1/Filaggrin/AKT therapeutic target.

bioRxiv · Mar 11, 2024 · PreprintCell Biology

Loss of cholesterol in Junctional Epidermolysis Bullosa skin identifies a key role for Laminin-332 in actomyosin mediated cholesterol transport

E. M. Jones, E. Camera, P. Parzymies, S. T. Marsh, R. F. O'Shaughnessy, M. Aumailley, J. A. McGrath, E. A. O'Toole, M. P. Caley

This study shows that loss of Laminin-332 in JEB disrupts cholesterol transport in keratinocytes, affecting epidermal lipid metabolism and barrier function.

bioRxiv · Sep 10, 2023 · PreprintCell Biology