K. Mills

Reduced Filaggrin expression induces dysregulated intracellular signalling in atopic eczema

This study identifies dysregulated BMP and ERK1/2/AKT signaling in FLG-deficient keratinocytes and AE biopsies, linking FLG loss to altered desmosomal proteins and suggesting a SMAD1/Filaggrin/AKT therapeutic target.

Allosteric Modulation of YAP/TAZ-TEAD Interaction by Palmitoylation and Small Molecule Inhibitors

This study uses molecular dynamics simulations to investigate how palmitoylation and inhibitors affect YAP/TAZ-TEAD interactions, revealing distinct binding mechanisms for the inhibitor.

The emergence of goblet inflammatory or ITGB6hi nasal progenitor cells determines age-associated SARS-CoV-2 pathogenesis

The study identifies age-related differences in nasal epithelial cell responses to SARS-CoV-2 infection, showing distinct progenitor cell dynamics in children and elderly.

Uncovering the Mechanism of the Proton-Coupled Fluoride Transport in the CLCF Antiporter

This study uses molecular dynamics simulations to uncover the mechanism of proton-coupled fluoride transport in the CLCF antiporter, revealing the role of specific residues and the coupling of proton and anion transport.

Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype

This study identifies TLR2 activation as a common mechanism in ichthyosis, showing it induces hyperkeratosis and alters keratin expression through NFκB and Gata3 pathways.

An Endogenously activated antiviral state restricts SARS-CoV-2 infection in differentiated primary airway epithelial cells

The paper shows that an endogenous IFNλ pathway provides resistance to SARS-CoV-2 in airway epithelial cells, with high baseline IFNλ correlating with resistance.

Collaboration Between Host and Viral Factors Shape SARS-CoV-2 Evolution

This study investigates how viral and host factors influence SARS-CoV-2 evolution in vitro, identifying genetic changes and their impact on viral fitness in different cell types.

Growth of tumor emboli within a vessel model reveals dependence on the magnitude of mechanical constraint.

This study shows that tumor emboli grow more in stiff vessel-like environments due to mechanical constraints, leading to increased tumor burden.

Chronic loss of STAG2 leads to altered chromatin structure contributing to de-regulated transcription in AML

This study shows that chronic STAG2 loss alters chromatin structure and deregulates transcription in AML, affecting HOXA and MAPK pathways.

Rapid fabrication of collagen bundles mimicking tumor-associated collagen signatures

This study develops a method to create collagen bundles that mimic tumor-associated collagen structures, showing enhanced cancer cell migration and invasion in vitro.