Structural Insights into Regulation of Insulin Expression Involving i-Motif DNA Structures in the Insulin-Linked Polymorphic Region.
D. Guneri, E. Alexandrou, K. El Omari, Z. Dvorakova, R. V. Chikhale, D. Pike, C. A. Waudby, C. J. Morris, S. Haider, G. N. Parkinson, Z. A. E. Waller
This study investigates how sequence variants in the insulin-linked polymorphic region form i-motif and G-quadruplex DNA structures, which regulate insulin gene expression.
bioRxiv · Jun 1, 2023 · PreprintBiophysics