Author

C. A. Waudby

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 4 Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 2 Organism:bacteria (other)· 1 Research Focus:cell signaling & trafficking· 1 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

J. Christodoulou· 4 shared A. Behrens· 1 shared A. Mylona· 1 shared A. N. Volkov· 1 shared B. Davis· 1 shared C. Burridge· 1 shared C. J. Morris· 1 shared D. Guneri· 1 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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4 shared papersBiophysics

J. Christodoulou

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Author profile →

6 papers

Recent·Most cited

Structural Insights into Regulation of Insulin Expression Involving i-Motif DNA Structures in the Insulin-Linked Polymorphic Region.

D. Guneri, E. Alexandrou, K. El Omari, Z. Dvorakova, R. V. Chikhale, D. Pike, C. A. Waudby, C. J. Morris, S. Haider, G. N. Parkinson, Z. A. E. Waller

This study investigates how sequence variants in the insulin-linked polymorphic region form i-motif and G-quadruplex DNA structures, which regulate insulin gene expression.

bioRxiv · Jun 1, 2023 · PreprintBiophysics

An intrinsic temporal order of c-Jun N-terminal phosphorylation regulates its activity by orchestrating co-factor recruitment

C. A. Waudby, S. Alvarez-Teijeiro, S. Suppinger, P. R. Brown, A. Behrens, J. Christodoulou, A. Mylona

The paper shows that c-Jun phosphorylation by JNK occurs in a defined temporal order, leading to distinct functional states that regulate signaling through co-factor recruitment.

bioRxiv · Nov 3, 2021Biochemistry

Optimal design of adaptively sampled NMR experiments for measurement of methyl group dynamics with application to a ribosome-nascent chain complex

C. A. Waudby, C. Burridge, J. Christodoulou

This paper develops an optimized NMR pulse sequence for measuring methyl group dynamics in ribosome-nascent chain complexes, enabling quantitative analysis of rotational diffusion and interactions.

Journal of Magnetic Resonance · May 1, 2021Peer-reviewedBiophysics

Analysis of Conformational Exchange Processes using Methyl-TROSY-Based Hahn Echo Measurements of Quadruple-Quantum Relaxation

C. A. Waudby, J. Christodoulou

The paper presents an experiment to measure chemical exchange in biomacromolecules using quadruple-quantum relaxation rates and Hahn echo measurements.

bioRxiv · Apr 11, 2021Biophysics

Catalysis by a rigid enzyme

F. Ben Bdira, C. A. Waudby, A. N. Volkov, S. Schroder, E. AB, J. Codee, H. S. Overkleeft, H. Aerts, H. van Ingen, M. Ubbink

The paper shows that the rigid xylanase enzyme uses substrate flexibility to facilitate catalysis without significant structural changes.

bioRxiv · Oct 24, 2019 · PreprintBiochemistry

Two-dimensional NMR lineshape analysis of single, multiple, zero and double quantum correlation experiments

C. A. Waudby, M. Ouvry, B. Davis, J. Christodoulou

This paper classifies chemical exchange regimes in 2D NMR spectra and introduces optimized experiments for improved analysis of molecular interactions.

bioRxiv · Sep 26, 2019Biophysics