Author

E. B. Speltz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

J. G. Zalatan· 2 shared E. Fagnan· 1 shared M. Gavagan· 1 shared

Activity by Year

2019-2020 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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2 shared papersBiochemistry

J. G. Zalatan

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2 papers

Recent·Most cited

The relationship between effective molarity and affinity governs rate enhancements in tethered kinase-substrate reactions

E. B. Speltz, J. G. Zalatan

This study quantifies how tethering affects kinase-substrate reaction rates and shows that effective molarity depends on tether structure and scaffold complex concentration.

bioRxiv · Mar 12, 2020Biochemistry

The Wnt pathway scaffold protein Axin promotes signaling specificity by suppressing competing kinase reactions

M. Gavagan, E. Fagnan, E. B. Speltz, J. G. Zalatan

The paper shows Axin enhances Wnt signaling specificity by reducing competition from non-Wnt substrates like CREB in GSK3β reactions.

bioRxiv · Sep 13, 2019Biochemistry