Author

M. Gavagan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

J. G. Zalatan· 2 shared E. B. Speltz· 1 shared E. Fagnan· 1 shared N. Jameson· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

4 top collaborators · 4 mutual co-author links

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2 shared papersBiochemistry

J. G. Zalatan

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2 papers

Recent·Most cited

The Axin scaffold protects the kinase GSK3β from cross-pathway inhibition

M. Gavagan, N. Jameson, J. G. Zalatan

This study shows that the Axin scaffold prevents GSK3β from being phosphorylated at Ser9 by upstream kinases, thereby protecting Wnt signaling from cross-pathway inhibition.

bioRxiv · Dec 5, 2022Biochemistry

The Wnt pathway scaffold protein Axin promotes signaling specificity by suppressing competing kinase reactions

M. Gavagan, E. Fagnan, E. B. Speltz, J. G. Zalatan

The paper shows Axin enhances Wnt signaling specificity by reducing competition from non-Wnt substrates like CREB in GSK3β reactions.

bioRxiv · Sep 13, 2019Biochemistry