MAP kinase ERK5 modulates cancer cell sensitivity to extrinsic apoptosis induced by death-receptor agonists and Natural Killer cells
S. Espinosa-Gil, S. Ivanova, E. Alari-Pahissa, M. Denizli, B. Villafranca-Magdalena, M. Vinas-Casas, I. Bolinaga-Ayala, A. Gamez-Garcia, E. Colas, M. Lopez-Botet, A. Zorzano, J. M. Lizcano
This study identifies ERK5 as a regulator of cancer cell resistance to TRAIL-induced apoptosis, showing that ERK5 inhibition sensitizes cancer cells to TRAIL and Natural Killer cell-mediated killing.
bioRxiv · Mar 22, 2023 · PreprintCancer Biology