A molecular plugin rescues GroEL/ES substrates from pre-folding oxidation
E. Dupuy, S. Van der Verren, J. Lin, M. A. Wilson, A. Dachsbeck, F. Viela, E. Latour, A. Gennaris, D. Vertommen, Y. F. Dufrene, B. I. Iorga, C. V. Goemans, H. Remaut, J.-F. Collet
This study identifies CnoX as a redox quality-control plugin for GroEL, showing it binds outside the substrate-binding site and forms mixed-disulfides with substrates.
bioRxiv · May 3, 2022 · PreprintBiochemistry