HIV-1 GAG SPECIFICITY FOR PIP2-CONTAINING MEMBRANES MIGHT BE DRIVEN BY MACROMOLECULAR ELECTRIC PROPERTIES RATHER THAN MOLECULAR AFFINITIES
L. B. Perez Socas, E. E. Ambroggio
This paper investigates how HIV-1 MA domain interacts with PIP2-containing membranes and finds that RNA and a GAG-derived peptide influence this interaction through electrostatic properties rather than direct molecular affinity.
bioRxiv · Aug 25, 2022 · PreprintCell Biology