Tyr1 phosphorylation promotes the phosphorylation of Ser2 on the C-terminal domain of RNA polymerase II by P-TEFb
Y. Zhang, J. E. Mayfield, S. Irani, E. E. Escobar, Z. Zhang, N. T. Burkholder, M. R. Robinson, M. R. Mehaffey, S. N. Sipe, W. Yang, N. A. Prescott, K. Kathuria, Z. Liu, J. Brodbelt
The paper shows Tyr1 phosphorylation directs P-TEFb to phosphorylate Ser2 on RNA polymerase II CTD, altering its specificity and expanding CTD modification coding potential.
bioRxiv · May 28, 2019Biochemistry