Complement activation by IgG subclasses is governed by their ability to oligomerize upon antigen binding
N. Frischauf, J. Strasser, E. G. F. Borg, A. F. Labrijn, F. J. Beurskens, J. Preiner
This study shows that IgG subclass complement activation depends on their ability to form oligomers on antigen surfaces, challenging the traditional view of C1 affinity.
bioRxiv · Mar 26, 2024Immunology