Author

F. J. Beurskens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

C. J. C. de Haas· 3 shared J. Preiner· 3 shared J. Schuurman· 3 shared J. Strasser· 3 shared P. Aerts· 3 shared A. J. R. Heck· 2 shared J. van Strijp· 2 shared K. P. M. van Kessel· 2 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersMicrobiology

C. J. C. de Haas

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4 papers

Recent·Most cited

Complement activation by IgG subclasses is governed by their ability to oligomerize upon antigen binding

N. Frischauf, J. Strasser, E. G. F. Borg, A. F. Labrijn, F. J. Beurskens, J. Preiner

This study shows that IgG subclass complement activation depends on their ability to form oligomers on antigen surfaces, challenging the traditional view of C1 affinity.

bioRxiv · Mar 26, 2024Immunology

Promoting Fc-Fc interactions between anti-capsular antibodies provides strong complement-dependent immune protection against Streptococcus pneumoniae

L. Aguinagalde, M. A. den Boer, S. Castenmiller, S. Zwarthoff, C. J. C. de Haas, P. Aerts, F. J. Beurskens, J. Schuurman, A. J. R. Heck, K. V. Kessel, S. Rooijakkers

This paper shows that modifying anti-capsular antibodies to enhance hexamerization improves complement activation and immune protection against Streptococcus pneumoniae.

bioRxiv · Jan 21, 2022Microbiology

C1q binding to surface-bound IgG is stabilized by C1r2s2 proteases

S. A. Zwarthoff, K. Widmer, A. Kuipers, J. Strasser, M. Ruyken, P. Aerts, C. J. C. de Haas, D. Ugurlar, G. Vidarsson, J. van Strijp, P. Gros, P. Parren, K. P. M. van Kessel, J. Preiner, F. J. Beurskens, , S. H. M. Rooijakkers

This study shows that C1r2s2 proteases stabilize C1q binding to surface-bound IgG, with subclass-specific effects and improved phagocytosis with hexamer-enhanced IgGs.

bioRxiv · Feb 8, 2021Immunology

Staphylococcal protein A inhibits complement activation by interfering with IgG hexamer formation

A. R. Cruz, M. A. den Boer, J. Strasser, F. J. Beurskens, C. J. C. de Haas, P. Aerts, G. Wang, R. N. de Jong, F. Bagnoli, J. van Strijp, K. P. M. van Kessel, J. Schuurman, J. Preiner, A. J. R. Heck, S. H. M. Rooijakkers

This study shows Staphylococcal protein A inhibits IgG hexamer formation, blocking complement activation, but IgG3 can still induce complement activation despite SpA.

bioRxiv · Jul 20, 2020Microbiology