SLC15A4 controls endolysosomal TLR7-9 responses by recruiting the innate immune adaptor TASL.
H. Zhang, L. Bernaleau, M. Delacretaz, E. Hasanovic, H. Eibel, M. Rebsamen
This study shows SLC15A4 recruits TASL to endolysosomes to control TLR7-9 signaling, independent of its transport function, and identifies this interaction as a therapeutic target for SLE.
bioRxiv · Mar 27, 2023Immunology