SapM mutation to improve the BCG vaccine: genomic, transcriptomic and preclinical safety characterization
N. Festjens, K. Vandewalle, E. Houthuys, E. Plets, D. Vanderschaeghe, K. Borgers, A. Van Hecke, P. Tiels, N. Callewaert
The paper characterizes a BCG vaccine mutant with a SapM mutation, showing improved safety and immune control, supporting its potential as a live attenuated TB vaccine.
bioRxiv · Dec 4, 2018Microbiology