N. Festjens

N-glycosylation engineering in chimeric antigen receptor T cells enhances anti-tumor activity

This study shows that removing N-glycan modifications in CAR T cells improves their anti-tumor activity against solid tumors and lymphomas.

Ring Finger Protein 213 Assembles into a Sensor for ISGylated Proteins with Antimicrobial Activity

This study identifies RNF213 as an ISG15-interacting sensor that detects ISGylated proteins and exhibits broad antimicrobial activity against multiple pathogens.

Exploration of synergistic action of cell wall-degrading enzymes against Mycobacterium tuberculosis

This study investigates the synergistic effects of cell wall-degrading enzymes against Mycobacterium tuberculosis using a novel microtiter assay and identifies potent enzyme combinations.

Use of a counterselectable transposon to create markerless knockouts from a 18,432-clone ordered M. bovis BCG mutant resource

The paper describes a method to generate markerless knockouts from a large transposon mutant library in M. bovis BCG, creating an ordered mutant resource targeting 83% of non-essential genes.

Reference genome for the WHO reference strain for Mycobacterium bovis BCG Danish, the present tuberculosis vaccine

The paper presents a completely assembled genome sequence of the WHO reference strain M. bovis BCG Danish 1331 using an integrated genome analysis workflow.

SapM mutation to improve the BCG vaccine: genomic, transcriptomic and preclinical safety characterization

The paper characterizes a BCG vaccine mutant with a SapM mutation, showing improved safety and immune control, supporting its potential as a live attenuated TB vaccine.