3D Spheroid Primary Human Hepatocytes for Prediction of Cytochrome P450 and Drug Transporter Induction
E. Jarvinen, H. S. Hammer, O. Potz, M. Ingelman-Sundberg, T. B. Stage
This study evaluates 3D spheroid primary human hepatocytes as a model to assess induction of CYP enzymes and drug transporters, showing strong correlation with clinical findings.
bioRxiv · Oct 30, 2022Pharmacology & Toxicology