Author

M. Ingelman-Sundberg

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 2

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Approach:deep learning· 1 Approach:experimental assay· 1 Assay:protein structure· 1 Assay:whole-exome sequencing· 1

Frequent Co-Authors

B. A. L. M. Deiman· 1 shared E. Jarvinen· 1 shared H. S. Hammer· 1 shared H.-J. Guchelaar· 1 shared I. Johansson· 1 shared J. J. Swen· 1 shared M. J. Deenen· 1 shared M. van der Lee· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperPharmacology & Toxicology

B. A. L. M. Deiman

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2 papers

Recent·Most cited

3D Spheroid Primary Human Hepatocytes for Prediction of Cytochrome P450 and Drug Transporter Induction

E. Jarvinen, H. S. Hammer, O. Potz, M. Ingelman-Sundberg, T. B. Stage

This study evaluates 3D spheroid primary human hepatocytes as a model to assess induction of CYP enzymes and drug transporters, showing strong correlation with clinical findings.

bioRxiv · Oct 30, 2022Pharmacology & Toxicology

A unifying model to predict variable drug response for personalised medicine

M. van der Lee, W. G. Allard, R. H. A. M. Vossen, R. F. Baak-Pablo, R. Menafra, B. A. L. M. Deiman, M. J. Deenen, P. Neven, I. Johansson, S. Gastaldello, M. Ingelman-Sundberg, H.-J. Guchelaar, J. J. Swen, S. Y. Anvar

The paper introduces a continuous scale model using full gene sequencing and neural networks to predict CYP2D6 enzyme activity, explaining 79% of interindividual variability in drug response.

bioRxiv · Mar 2, 2020Pharmacology & Toxicology