A protease-initiated model of wound detection
J. T. O'Connor, A. C. Stevens, E. K. Shannon, F. B. Akbar, K. S. LaFever, N. Narayanan, M. S. Hutson, A. Page-McCaw
The paper identifies a protease-initiated signal transduction pathway that enables epithelial cells to detect wounds through the activation of Gbp ligands and Mthl10 receptors, leading to calcium release.
bioRxiv · Dec 8, 2020Cell Biology