E. L. Wise

Translational arrest and mRNA decay are independent activities of alphaherpesvirus virion host shutoff proteins

This study compares alphaherpesvirus vhs proteins to determine if translational arrest and mRNA decay are separate functions, finding that some induce mRNA decay while others cause translational arrest without decay.

Herpes simplex virus 1 expressing GFP-tagged virion host shutoff (vhs) protein uncouples the activities of degradation and nuclear retention of the infected cell transcriptome

This paper shows that HSV1's vhs protein can retain infected cell transcripts in the nucleus without degrading them, uncoupling these two functions.