Preferential phosphatidylinositol 5-phosphate binding contributes to a destabilization of the VHS domain structure of Tom1
W. Xiong, T.-X. Tang, E. Littleton, A. Karcini, I. M. Lazar, D. G. S. Capelluto
This study shows that PtdIns5P binding destabilizes the Tom1 VHS domain structure, affecting its function and contributing to bacterial survival during Shigella infection.
bioRxiv · Jun 14, 2019Biophysics