Author

W. Xiong

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5 Cell Biology· 3 Plant Biology· 3 Bioengineering· 2 Biophysics· 2 Physiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 13 Organism:mouse· 7 Assay:electrophysiology· 5 Approach:statistical model· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:cell type annotation· 3 Research Focus:chromatin & epigenetic regulation· 3

Frequent Co-Authors

N. Zhang· 3 shared Z. An· 3 shared A. Yamaguchi· 2 shared J. Sun· 2 shared K. Tsuchikama· 2 shared L. Xu· 2 shared M. E. Schranz· 2 shared R. Chai· 2 shared

Activity by Year

2018-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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3 shared papersBioengineering

N. Zhang

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18 papers

Recent·Most cited

Single phage proteins sequester TIR- and cGAS-generated signaling molecules

D. Li, Y. Xiao, W. Xiong, I. Fedorova, Y. Wang, X. Liu, E. Huiting, J. Ren, Z. Gao, X. Zhao, X. Cao, Y. Zhang, J. Bondy-Denomy, Y. Feng

This study identifies Tad1 and Tad2 as phage proteins that sequester cyclic nucleotides produced by TIR and cGAS systems to inhibit anti-phage immunity.

bioRxiv · Nov 15, 2023 · PreprintMicrobiology

A force-sensitive adhesion GPCR is indispensable in normal equilibrioception

Z. Yang, S. Zhou, Q. Zhang, Z. Song, W. Liu, Y. Sun, M. Wang, X. Fu, K. Zhu, Y. Guan, J. Qi, X. Wang, Y. Sun, Y. Lu, Y. Ping, , J. Sun

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

bioRxiv · Oct 24, 2023 · PreprintPhysiology

The force-sensing GPCR LPHN2 is indispensable for normal auditory function

Z. Yang, M.-W. Wang, S.-H. Zhou, Z.-c. Song, K.-K. Zhu, X. Wen, Q.-Y. Zhang, Y. Guan, J.-R. Gao, X.-H. Wang, Y.-Q. Wang, W.-W. Liu, L. Xu, W. Xiong, R. Chai, , J.-P. Sun

This study identifies LPHN2 as a force-sensing GPCR critical for auditory function, showing its role in mechanoelectrical transduction and hearing loss when deficient.

bioRxiv · Oct 24, 2023 · PreprintPhysiology

TFEB degradation is regulated by an IKK/β-TrCP2 phosphorylation-ubiquitination cascade

Y. Xiong, J. Sharma, M. N. Young, W. Xiong, A. Jazayeri, K. F. Poncha, M. X. Ilagan, Q. Wang, H. Zheng, N. L. Young, M. Sardiello

This study identifies an IKK/β-TrCP2 phosphorylation-ubiquitination cascade that regulates TFEB stability, independent of other regulators.

bioRxiv · Oct 16, 2023Cell Biology

PKA regulation of neuronal function requires the dissociation of catalytic subunits from regulatory subunits

W. Xiong, M. Qin, H. Zhong

This study shows that PKA catalytic subunits dissociate from regulatory subunits in neurons upon activation, which is necessary for synaptic plasticity and transmission.

bioRxiv · Sep 5, 2023Cell Biology

Genome assembly and analysis of Lactuca virosa: implications for lettuce breeding

W. Xiong, D.-J. M. van Workum, L. Berke, L. V. Bakker, E. Schijlen, F. F. M. F. M. Becker, H. van de Geest, S. Peters, R. Michelmore, R. van Treuren, M. J. W. Jeuken, S. Smit, M. E. Schranz

This study presents a high-quality genome assembly of Lactuca virosa and analyzes its genetic variation compared to related species, identifying genomic features that may impact lettuce breeding.

bioRxiv · May 3, 2023 · PreprintPlant Biology

The genome of Gynandropsis gynandra provides insights into whole-genome duplications and the evolution of C4 photosynthesis in Cleomaceae

N. V. Hoang, E. O. D. Sogbohossou, W. Xiong, C. J. C. Simpson, P. Singh, E. van den Bergh, X.-G. Zhu, A. Brautigam, A. P. M. Weber, J. C. van Haarst, E. G. W. M. Schijlen, P. S. Hendre, A. Van Deynze, E. G. Achigan-Dako, J. M. Hibberd, M. E. Schranz

This study presents the genome of Gynandropsis gynandra, revealing whole-genome duplications and gene retention patterns related to C4 photosynthesis evolution in Cleomaceae.

bioRxiv · Jul 9, 2022Plant Biology

An updated nomenclature for plant ribosomal protein genes

M. R. Scarpin, M. Busche, R. E. Martinez, L. C. Harper, L. Reiser, T. Lan, W. Xiong, B. Mo, G. Tang, X. Chen, J. Bailey-Serres, K. Browning, J. O. Brunkard

The paper proposes updated nomenclature for plant ribosomal protein genes to improve adoption in plant biology, extending previous systems to include organellar ribosomes and additional species.

bioRxiv · Jul 6, 2022Plant Biology

Engineering SARS-CoV-2 cocktail antibodies into a bispecific format improves neutralizing potency and breadth

Z. Ku, X. Xie, J. Lin, P. Gao, A. E. Sahili, H. Su, Y. Liu, X. Ye, X. Li, X. Fan, B. C. Goh, W. Xiong, H. Boyd, A. E. Muruato, H. Deng, , Z. An

This study engineers bispecific antibodies against SARS-CoV-2, showing that one design outperforms a cocktail in neutralizing activity and breadth against variants.

bioRxiv · Feb 1, 2022 · PreprintMicrobiology

Homogeneity of antibody-drug conjugates critically impacts the therapeutic efficacy in brain tumors

Y. Anami, Y. Otani, W. Xiong, S. Y. Y. Ha, A. Yamaguchi, N. Zhang, Z. An, B. Kaur, K. Tsuchikama

This study shows that homogeneous antibody-drug conjugates (ADCs) improve therapeutic efficacy in glioblastoma models compared to heterogeneous ADCs.

bioRxiv · Dec 23, 2021Bioengineering

Active anaerobic methane oxidation and sulfur disproportionation in the deep terrestrial subsurface

E. Bell, T. Lamminmaki, J. Alneberg, C. Qian, W. Xiong, R. L. Hettich, M. Frutschi, R. Bernier-Latmani

The paper demonstrates active anaerobic methane oxidation and sulfur disproportionation in deep terrestrial subsurface environments using metaproteogenomics and isotopic analysis.

bioRxiv · Aug 21, 2021Microbiology

Minimal-invasive enhancement of auditory perception by terahertz wave modulation

X. Tan, K. Wu, S. Liu, C. Chang, W. Xiong

This study introduces terahertz wave modulation to enhance hearing perception in animals by increasing cochlear hair cell currents and sensitivity without genetic modification.

bioRxiv · Jun 1, 2021Biophysics

Antibody-drug conjugates with dual payloads for combating breast tumor heterogeneity and drug resistance

C. M. Yamazaki, A. Yamaguchi, Y. Anami, W. Xiong, Y. Otani, J. Lee, N. T. Ueno, N. Zhang, Z. An, K. Tsuchikama

This study develops dual-payload antibody-drug conjugates to overcome breast tumor heterogeneity and drug resistance, showing improved efficacy in a xenograft model.

bioRxiv · Dec 18, 2020Bioengineering

Development of a simple in vitro assay to identify and evaluate nucleotide analogs against SARS-CoV-2 RNA-dependent RNA polymerase

G. Lu, X. Zhang, W. Zheng, J. Sun, L. Hua, L. Xu, X.-j. Chu, S. Ding, W. Xiong

This paper develops an in vitro assay to evaluate nucleotide analogs against SARS-CoV-2 RdRp, showing varying incorporation efficiencies and chain termination effects.

bioRxiv · Jul 16, 2020Biochemistry

Isopropoxy benzene guanidine kills Staphylococcus aureus without detectable resistance

X. Zhang, X. Peng, Y. Lu, J. Hao, F. Li, Z. Qin, W. Xiong, Z. Zeng

This study evaluates isopropoxy benzene guanidine's antimicrobial activity against S. aureus, showing potent activity and low resistance potential.

bioRxiv · Mar 10, 2020Microbiology

Preferential phosphatidylinositol 5-phosphate binding contributes to a destabilization of the VHS domain structure of Tom1

W. Xiong, T.-X. Tang, E. Littleton, A. Karcini, I. M. Lazar, D. G. S. Capelluto

This study shows that PtdIns5P binding destabilizes the Tom1 VHS domain structure, affecting its function and contributing to bacterial survival during Shigella infection.

bioRxiv · Jun 14, 2019Biophysics

TMC1 confers a leak conductance to modulate excitability of auditory hair cells in mammals

W. Xiong, S. Liu, S. Wang, L. Zou, J. Li, C. Song, J. Chen, Q. Hu, L. Liu

This study identifies TMC1 as providing a background leak conductance in mouse auditory hair cells, essential for action potential firing and tonotopic organization.

bioRxiv · Apr 24, 2019 · PreprintCell Biology

Hospitalized premature infants are colonized by related bacterial strains with distinct proteomic profiles

C. T. Brown, W. Xiong, M. R. Olm, B. C. Thomas, R. Baker, B. Firek, M. J. Morowitz, R. L. Hettich, J. F. Banfield

This study examines microbial colonization in premature infants, finding distinct proteomic profiles among related bacterial strains and correlations with NEC development.

bioRxiv · Mar 6, 2018Microbiology