I. M. Lazar

Proteomic Assessment of SKBR3/HER2+ Breast Cancer Cellular Response to Lapatinib and Investigational Ipatasertib Kinase Inhibitors

This study uses proteomic analysis to evaluate the response of HER2+ breast cancer cells to Lapatinib and Ipatasertib, identifying proteins and pathways affected by these drugs.

Proteomic Insights into Breast Cancer Response to Brain Cell-Secreted Factors

This study investigates how HER2+ breast cancer cells respond to brain cell-secreted factors, finding that exposure leads to quiescence and altered cellular processes.

Mapping the Cell-Membrane Proteome to the Cancer Hallmarks

This paper maps cell-membrane proteins to cancer hallmarks to identify novel therapeutic targets and network hubs.

The SKBR3 Cell-Membrane Proteome: Role in Aberrant Cancer Cell Proliferation and Resource for Precision Medicine Applications

This study characterizes the SKBR3 cell-membrane proteome, identifying numerous tumor markers and drug targets, and reveals its role in cancer proliferation and therapeutic resistance.

Systems-Level Proteomics Evaluation of Microglia Response to Tumor-Supportive Anti-inflammatory Cytokines

The paper uses proteomics to analyze how microglia respond to anti-inflammatory cytokines, identifying tumor-promoting processes and signaling pathways involved.

Preferential phosphatidylinositol 5-phosphate binding contributes to a destabilization of the VHS domain structure of Tom1

This study shows that PtdIns5P binding destabilizes the Tom1 VHS domain structure, affecting its function and contributing to bacterial survival during Shigella infection.