Reactive Centre Loop Dynamics and Serpin Specificity
E. M. Marijanovic, J. Fodor, B. T. Riley, B. T. Porebski, M. G. Costa, I. Kass, D. E. Hoke, S. McGowan, A. M. Buckle
This study investigates serpin specificity by engineering the reactive centre loop (RCL) of a synthetic serpin, finding that RCL sequence alone does not determine specificity, and that local electrostatics and dynamics also play critical roles.
bioRxiv · Aug 14, 2018Biochemistry