Author

M. G. Costa

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:comparative / phylogenetic analysis· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Assay:structural biology· 1

Frequent Co-Authors

A. M. Buckle· 2 shared B. T. Porebski· 2 shared D. E. Hoke· 2 shared J. Fodor· 2 shared S. McGowan· 2 shared B. T. Riley· 1 shared C. F. Reboul· 1 shared D. Christ· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersBiochemistry

A. M. Buckle

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2 papers

Recent·Most cited

Structure and dynamics of the autoantigen GAD65 in complex with the human autoimmune polyendocrine syndrome type 2-associated autoantibody b96.11

S. Stander, C. F. Reboul, S. N. Lee, D. Williams, P. G. Chandler, M. G. Costa, D. E. Hoke, J. D. Jimma, J. Fodor, G. Fenalti, S. I. Mannering, B. T. Porebski, P. Schofield, D. Christ, M. Buckle, , A. M. Buckle

This study characterizes the structure and dynamics of GAD65 and its interaction with autoantibody b96.11, revealing how intrinsic conformational flexibility drives autoantigenicity.

bioRxiv · Mar 18, 2024 · PreprintBiochemistry

Reactive Centre Loop Dynamics and Serpin Specificity

E. M. Marijanovic, J. Fodor, B. T. Riley, B. T. Porebski, M. G. Costa, I. Kass, D. E. Hoke, S. McGowan, A. M. Buckle

This study investigates serpin specificity by engineering the reactive centre loop (RCL) of a synthetic serpin, finding that RCL sequence alone does not determine specificity, and that local electrostatics and dynamics also play critical roles.

bioRxiv · Aug 14, 2018Biochemistry