Accurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson’s disease
O. Karayel, F. Tonelli, S. Virreira Winter, P. E. Geyer, Y. Fan, E. M. Sammler, D. R. Alessi, M. Steger, M. Mann
The paper develops an ultra-sensitive MS-based assay to measure Rab10-Thr73 phosphorylation stoichiometry as a biomarker for LRRK2 activity in Parkinson’s disease.
bioRxiv · Oct 25, 2019Biochemistry