Author

O. Karayel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 4 Cell Biology· 2

Signature Assays, Organisms & Methods

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Assay:proteomics· 6 Approach:experimental assay· 5 Organism:human· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:protein folding & dynamics· 2 Approach:statistical model· 2 Organism:yeast· 2

Frequent Co-Authors

M. Mann· 6 shared D. Sherpa· 3 shared F. M. Hansen· 3 shared J. Chrustowicz· 3 shared A. F. Alpi· 2 shared B. Schulman· 2 shared C. R. Langlois· 2 shared K. V. Gottemukkala· 2 shared

Activity by Year

2019-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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6 shared papersBiochemistry

M. Mann

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Author profile →

6 papers

Recent·Most cited

Rapid and in-depth coverage of the (phospho-)proteome with deep libraries and optimal window design for dia-PASEF

P. Skowronek, M. Thielert, E. Voytik, M. C. Tanzer, F. M. Hansen, S. Willems, O. Karayel, A.-D. Brunner, F. Meier, M. Mann

This paper introduces an optimized dia-PASEF method with variable isolation windows to enhance proteome and phosphoproteome coverage in mass spectrometry.

bioRxiv · May 31, 2022Biochemistry

Mitochondrial phosphoproteomes are functionally specialized across tissues

M. Mann, F. M. Hansen, L. S. Kremer, O. Karayel, I. Kühl, I. Bludau, N.-G. Larsson

The paper quantitatively profiles mitochondrial proteomes and phosphoproteomes across multiple tissues in mice, revealing tissue-specific kinase and phosphatase repertoires and functional phosphorylation events.

bioRxiv · Mar 23, 2022Biochemistry

Differential UBE2H-CTLH E2-E3 ubiquitylation modules regulate erythroid maturation

D. Sherpa, J. Mueller, O. Karayel, J. Chrustowicz, P. Xu, K. V. Gottemukkala, C. Baumann, A. Gross, O. Czarnezki, W. Zhang, J. Gu, J. Nilvebrant, M. J. Weiss, S. Sidhu, P. J. Murray, , A. F. Alpi

The paper identifies UBE2H-CTLH ubiquitylation modules that regulate stages of human erythropoiesis, showing their role in controlling maturation and heme synthesis.

bioRxiv · Jan 18, 2022 · PreprintCell Biology

A GID E3 ligase assembly ubiquitinates an Rsp5 E3 adaptor and regulates plasma membrane transporters

C. R. Langlois, V. Beier, O. Karayel, J. Chrustowicz, D. Sherpa, M. Mann, B. Schulman

The paper shows that the GID E3 ligase system regulates plasma membrane transporters through a stress-specific substrate receptor, Gid10, and ubiquitinates Art2.

bioRxiv · Sep 2, 2021Cell Biology

GID E3 ligase supramolecular chelate assembly configures multipronged ubiquitin targeting of an oligomeric metabolic enzyme

D. Sherpa, J. Chrustowicz, S. Qiao, C. R. Langlois, L. A. Hehl, K. V. Gottemukkala, F. M. Hansen, O. Karayel, S. von Gronau, J. R. Prabu, M. Mann, A. F. Alpi, B. A. Schulman

The paper reveals a supramolecular chelate assembly mechanism by which E3 ligases target oligomeric substrates, demonstrating this in yeast and human orthologs.

bioRxiv · Apr 7, 2021Biochemistry

Accurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson’s disease

O. Karayel, F. Tonelli, S. Virreira Winter, P. E. Geyer, Y. Fan, E. M. Sammler, D. R. Alessi, M. Steger, M. Mann

The paper develops an ultra-sensitive MS-based assay to measure Rab10-Thr73 phosphorylation stoichiometry as a biomarker for LRRK2 activity in Parkinson’s disease.

bioRxiv · Oct 25, 2019Biochemistry