Consequences of aneuploidy in human fibroblasts with trisomy 21
S. Hwang, P. Cavaliere, R. Li, L. J. Zhu, N. Dephoure, E. M. Torres
This study analyzes transcriptome, proteome, and phenotypic changes in trisomy 21 fibroblasts, revealing increased gene and protein expression and aneuploidy-related phenotypes like reduced viability and reliance on serine-driven lipid biosynthesis.
bioRxiv · Aug 14, 2020Cell Biology