N. Dephoure

The tissue-specific autophagic response to nutrient deprivation

This study examines how liver and brain cells use autophagy under normal and nutrient-deprived conditions, revealing tissue-specific differences in organelle turnover and cargo capture.

Radiation therapy promotes unsaturated fatty acids to maintain survival of glioblastoma

This study shows that radiation therapy promotes unsaturated fatty acid accumulation in glioblastoma, enhancing survival by reducing ER stress, and that targeting lipid metabolism could improve treatment outcomes.

Proximity proteome mapping reveals PD-L1-dependent pathways disrupted by anti-PD-L1 antibody specifically in EGFR-mutant lung cancer cells.

The paper uses proximity proteome mapping to show that anti-PD-L1 therapy disrupts specific PD-L1-dependent pathways in EGFR-mutant lung cancer cells, leading to altered cell migration and EGFR stability.

Role of Specialized mSWI/SNF Complexes in Prostate Cancer Lineage Plasticity

The paper investigates the role of mSWI/SNF complexes in NEPC lineage plasticity using patient data and cell models, finding deregulated subunits and SMARCA4 overexpression linked to aggressive disease.

Consequences of aneuploidy in human fibroblasts with trisomy 21

This study analyzes transcriptome, proteome, and phenotypic changes in trisomy 21 fibroblasts, revealing increased gene and protein expression and aneuploidy-related phenotypes like reduced viability and reliance on serine-driven lipid biosynthesis.

Age-induced methylmalonic acid accumulation promotes tumor progression and aggressiveness

The paper shows that methylmalonic acid accumulation with age promotes tumor progression by inducing SOX4 and reprogramming cancer cells.

Robust, reproducible, and economical phosphopeptide enrichment using calcium titanate

The paper introduces a cost-effective and robust phosphopeptide enrichment method using calcium titanate, achieving results comparable to TiO2-based methods.

A conserved signaling network monitors delivery of sphingolipids to the plasma membrane in budding yeast

The paper identifies a conserved signaling network that responds to sphingolipid delivery to the plasma membrane in budding yeast, linking membrane growth to cell cycle and ribosome biogenesis.