S. Hwang

FGF2 binds to the allosteric site (site 2) and activates integrin αIIbβ3 and FGF1 binds to site 2 but suppresses integrin activation by FGF2: A potential mechanism of anti-thrombotic action of FGF1.

This study shows FGF2 activates integrin αIIbβ3 via site 2, while FGF1 binds site 2 but inhibits FGF2-induced activation, suggesting FGF1's anti-thrombotic mechanism.

FGF2 binds to the allosteric site (site 2) and activates αvβ3 integrin and FGF1 binds to site 2 but suppresses integrin activation by FGF2: a potential mechanism of anti-inflammatory action of FGF1

This study shows FGF2 activates αvβ3 integrin via site 2, while FGF1 binds site 2 but suppresses integrin activation, suggesting FGF1's anti-inflammatory action is through blocking site 2.

Autophagy regulates tumor growth and metastasis

This study shows that autophagy inhibition stabilizes Twist1 via p62, promoting tumor growth and metastasis in skin and melanoma models.

Growth Dynamics of Ductal Carcinoma in Situ Recapitulate Normal Breast Development

This study reconstructs DCIS growth dynamics using somatic mutation topography, revealing a multiclonal, branching morphogenesis-like pattern consistent with a new Comet model of tumorigenesis.

Unveiling the enigma of Brain-resident immune cells

This study identifies distinct brain-resident immune cell populations with unique transcriptional profiles, showing age-related changes and altered interactions in Alzheimer's disease.

TroR is the primary regulator of the iron homeostasis transcription network in the halophilic archaeon Haloferax volcanii

The paper identifies TroR as the primary regulator of iron homeostasis in Haloferax volcanii and shows it represses iron uptake and induces storage under iron sufficiency.

Structure of the Wnt-Frizzled-LRP6 initiation complex reveals the basis for co-receptor discrimination

The paper determines the structure of a ternary Wnt-Frizzled-LRP6 complex, revealing how co-receptor discrimination occurs through specific domains.

Robust and durable prophylactic protection conferred by RNA interference in preclinical models of SARS-CoV-2

This study identifies two siRNA combinations that provide robust prophylactic protection against SARS-CoV-2 in hamsters by reducing viral load and preventing lung pathology.

TrmB family transcription factor as a thiol-based regulator of oxidative stress response

This paper identifies TrmB-like proteins as thiol-based regulators of oxidative stress response in archaea, showing OxsR functions as both activator and repressor during hypochlorite stress.

Population size mediates the contribution of high-rate and large-benefit mutations to parallel evolution

The paper shows that small and large bacterial populations adapt to an antibiotic using different mutation types, with small populations favoring high-rate mutations and large populations favoring low-rate, high-benefit mutations.

The special and general mechanism of cyanobacterial harmful algal blooms

The paper examines the special and general mechanisms of cyanobacterial harmful algal blooms, identifying ecological and evolutionary factors that enable cyanobacteria to dominate under eutrophic conditions.

Structural and mechanistic insight into CRISPR-Cas9 inhibition by anti-CRISPR protein AcrIIC4

This study investigates how AcrIIC4 inhibits CRISPR-Cas9 by binding to its Recognition Domain and blocking DNA cleavage through conformational changes.

Autophagy gene-dependent intracellular immunity triggered by interferon-γ

This paper identifies new ATG genes and pathways involved in IFN-γ-induced intracellular immunity against norovirus and Toxoplasma gondii.

The dual function monoclonal antibodies VIR-7831 and VIR-7832 demonstrate potent in vitro and in vivo activity against SARS-CoV-2

This paper evaluates the in vitro and in vivo efficacy of dual-action monoclonal antibodies VIR-7831 and VIR-7832 against SARS-CoV-2, showing potent neutralization and reduced viral load in a hamster model.

Preclinical drug response metric based on cellular response phenotype provides better pharmacogenomic variables with phenotype relevance

This paper introduces a phenotype-based drug response metric that improves pharmacogenomic analysis by providing time-independent and phenotype-relevant assessments of drug effects.

Designed PKC-targeting bryostatin analogs modulate innate immunity and neuroinflammation

The paper shows that bryologs, synthetic analogs of bryostatin-1, reduce neuroinflammation by targeting PKC in innate immune cells, suggesting their potential as therapeutic agents for neuroinflammatory diseases.

Consequences of aneuploidy in human fibroblasts with trisomy 21

This study analyzes transcriptome, proteome, and phenotypic changes in trisomy 21 fibroblasts, revealing increased gene and protein expression and aneuploidy-related phenotypes like reduced viability and reliance on serine-driven lipid biosynthesis.

SDE2 Integrates into the TIMELESS-TIPIN Complex to Protect Stalled Replication Forks

This study identifies SDE2's role in stabilizing the TIMELESS-TIPIN complex to protect stalled replication forks and maintain genomic integrity.

Simple Behavioral Analysis (SimBA): an open source toolkit for computer classification of complex social behaviors in experimental animals

SimBA provides an open-source toolkit for automated classification of rodent social behaviors using machine learning, offering high accuracy and ease of use without requiring specialized hardware or programming knowledge.

Dynamin-related Irgm proteins modulate LPS-induced caspase-4 activation and septic shock

This study identifies Irgm proteins as negative regulators of caspase-4 activation in response to LPS, showing their role in preventing septic shock.

Genotypic complexity of Fisher’s geometric model

The paper analyzes Fisher's geometric model to compute the probability of sign epistasis and the complexity of fitness landscapes, showing that phenotypic dimension does not generally correlate with landscape complexity.

Mutation supply and the repeatability of selection for antibiotic resistance

This study investigates how mutation supply and selective pressure affect the repeatability of antibiotic resistance evolution in E. coli using mutant libraries.