L. J. Zhu

Calcineurin promotes adaptation to chronic stress through two distinct mechanisms

This study shows calcineurin (CN) helps yeast adapt to chronic stress through two distinct mechanisms involving Crz1 and Crz1-independent pathways.

Inhibiting the GPI Transamidase Subunit GPAA1 Abolishes CD24 Surface Localization and Enhances Macrophage-Mediated Phagocytosis of Ovarian Cancer Cells

This study identifies GPAA1 as a regulator of CD24 surface expression and shows that inhibiting GPAA1 enhances macrophage-mediated phagocytosis of ovarian cancer cells.

Nanoparticle delivery of innate immune agonists combines with senescence-inducing agents to mediate T cell control of pancreatic cancer

This paper combines nanoparticle-delivered immune agonists with senescence-inducing agents to enhance T cell responses and control pancreatic cancer in preclinical models.

A novel batokine Breg controls adipose thermogenesis and glucose homeostasis

This study identifies Breg as a batokine that regulates adipose thermogenesis and glucose homeostasis, showing its role in energy metabolism and potential therapeutic applications.

Phosphosite Scanning reveals a complex phosphorylation code underlying CDK-dependent activation of Hcm1

The paper introduces Phosphosite Scanning to identify functionally important phosphosites in multisite phosphorylated domains, demonstrating its application to Hcm1 in yeast.

EZH2 inhibition remodels the inflammatory senescence-associated secretory phenotype to potentiate pancreatic cancer immune surveillance

This study shows that inhibiting EZH2 enhances pro-inflammatory SASP in pancreatic cancer, improving NK and T cell infiltration and tumor control in mouse models.

The chromatin-binding domain of Ki-67 together with p53 protects human chromosomes from mitotic damage

This study shows that the C-terminal chromatin-binding domain of Ki-67, along with p53, prevents mitotic chromosome damage in human cells.

Consequences of aneuploidy in human fibroblasts with trisomy 21

This study analyzes transcriptome, proteome, and phenotypic changes in trisomy 21 fibroblasts, revealing increased gene and protein expression and aneuploidy-related phenotypes like reduced viability and reliance on serine-driven lipid biosynthesis.

Replication gaps underlie BRCA-deficiency and therapy response

This study challenges the existing model of BRCA-deficiency hypersensitivity to chemotherapy by proposing that ssDNA replication gaps, rather than DNA double strand breaks or stalled forks, underlie the therapeutic response.

The coordinate actions of calcineurin and Hog1 mediate the response to cellular stress through multiple nodes of the cell cycle network

This study shows calcineurin and Hog1 coordinate to control the cell cycle during stress by modulating transcription factors at multiple regulatory nodes.