Loss of cyclin A2 in murine colonic epithelial cells disrupts colon homeostasis by triggering DNA damage and dysplasia and high cyclin A2 expression is a good-prognosis factor in patients with colorectal cancer
Y. Guo, M. Gabola, R. Lattanzio, C. Paul, V. Pinet, R. Tang, H. Tulari, J. Bremond, C. Maurizy, Q. Da Costa, P. Finetti, F. Boissiere-Michot, C. Lemmers, S. Garnier, F. Bertucci, , M. Hahne
This study shows that loss of cyclin A2 in colonic epithelial cells causes DNA damage, dysplasia, and colon inflammation, while high cyclin A2 expression is linked to better prognosis in colorectal cancer.
bioRxiv · Jul 3, 2019 · PreprintCancer Biology