Author

C. Paul

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 2

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cancer & tumor microenvironment· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

B. Lemmers· 2 shared C. Maurizy· 2 shared H. Tulari· 2 shared J. Bremond· 2 shared M. Hahne· 2 shared R. Lattanzio· 2 shared R. Tang· 2 shared V. Pinet· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersCancer Biology

B. Lemmers

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Author profile →

5 papers

Recent·Most cited

Myocardial IGF2R is a critical mediator of inflammation and fibrosis after ischemia-reperfusion injury

Z. Wu, W. Huang, X. He, S. Dutta, C. Paul, G.-C. Fan, O. Kanisicak, M. Xu, J. Liang, Y. Wang

This study investigates the role of IGF2R in myocardial ischemia-reperfusion injury, finding it promotes inflammation and fibrosis and is a potential therapeutic target.

bioRxiv · Apr 21, 2023 · PreprintCell Biology

Single nucleus and spatial transcriptomic profiling of human healthy hamstring tendon

J. Y. Mimpen, L. D. Ramos-Mucci, C. Paul, A. Kurjan, P. Hulley, C. Ikwuanusi, S. Gwilym, M. J. Baldwin, A. P. Cribbs, S. J. B. Snelling

This study profiles the transcriptome and spatial distribution of cell types in healthy human hamstring tendon using snRNA-seq and spatial transcriptomics, identifying 12 cell types and highlighting fibroblasts' role in tissue homeostasis.

bioRxiv · Dec 19, 2022Cell Biology

IRF4 deficiency vulnerates B cell progeny for leukemogenesis via somatically acquired Jak3 mutations conferring IL-7 hypersensitivity

D. Das Gupta, C. Paul, N. Samel, M. Bieringer, D. Staudenraus, F. Marini, H. Raifer, L. Menke, L. Hansal, B. Camara, E. Roth, P. Daum, M. Wanzel, M. Mernberger, A. Nist, , M. Lohoff

This study shows IRF4 deficiency leads to B cell leukemia via Jak3 mutations that increase IL-7 sensitivity, and JAK inhibition improves survival in a mouse model.

bioRxiv · Feb 16, 2022 · PreprintCancer Biology

Partial loss of colonic primary cilia promotes inflammation and carcinogenesis

R. Tang, C. Paul, R. Lattanzio, T. Eguether, H. Tulari, J. Bremond, C. Maurizy, S. Poupeau, A. Turtoi, M. Svrcek, P. Seksik, V. Castronovo, P. Delvenne, B. Lemmers, C. Janke, , M. Hahne

This study shows that reduced colonic primary cilia in fibroblasts promotes inflammation and cancer in mouse models and human disease.

bioRxiv · Dec 20, 2019 · PreprintCancer Biology

Loss of cyclin A2 in murine colonic epithelial cells disrupts colon homeostasis by triggering DNA damage and dysplasia and high cyclin A2 expression is a good-prognosis factor in patients with colorectal cancer

Y. Guo, M. Gabola, R. Lattanzio, C. Paul, V. Pinet, R. Tang, H. Tulari, J. Bremond, C. Maurizy, Q. Da Costa, P. Finetti, F. Boissiere-Michot, C. Lemmers, S. Garnier, F. Bertucci, , M. Hahne

This study shows that loss of cyclin A2 in colonic epithelial cells causes DNA damage, dysplasia, and colon inflammation, while high cyclin A2 expression is linked to better prognosis in colorectal cancer.

bioRxiv · Jul 3, 2019 · PreprintCancer Biology