Hepatocyte-specific deletion of Pparα promotes NASH in the context of obesity
M. Regnier, A. Polizzi, S. Smati, C. Lukowicz, A. Fougerat, Y. Lippi, E. Fouche, F. Lasserre, C. Naylies, C. Betoulieres, V. Barquissau, E. Mouisel, J. Bertrand-Michel, A. Batut, T. Al Saati, , A. Montagner
This study shows that deleting Ppar in hepatocytes promotes NASH in obese mice without glucose intolerance, highlighting the role of extra-hepatocyte PPAR in metabolic responses to HFD.
bioRxiv · Jan 18, 2019 · PreprintPathology