J. Bertrand-Michel

p110alpha-dependent hepatocyte signaling is critical for liver gene expression and its rewiring in MASLD

This study investigates the role of p110alpha in hepatocyte signaling, showing its critical impact on liver gene expression and its rewiring in MASLD.

PIEZO1 force sensing controls global lipid homeostasis

This study shows that endothelial PIEZO1 force sensing regulates lipid homeostasis by affecting cholesterol metabolism and excretion, with implications for hyperlipidaemia.

Obesity promotes Fumonisin B1 toxicity and induces hepatitis

This study shows that obesity increases susceptibility to fumonisin B1 toxicity, leading to gut dysbiosis and severe liver inflammation.

De novo synthesized polyunsaturated fatty acids operate as both host immunomodulators and nutrients for Mycobacterium tuberculosis

This study shows that Mycobacterium tuberculosis uses host-derived arachidonic acid, a polyunsaturated fatty acid, for growth and immune evasion.

Pancreatic Cancer Intrinsic PI3Kα Activity accelerates Metastasis and rewires Macrophage Component

This paper identifies PI3K pathway activation as a driver of metastatic progression in pancreatic cancer and shows that targeting PI3K can delay macro-metastatic evolution.

Lipid membranes from naked mole-rat brain lipids are cholesterol-rich, highly phase-separated, and sensitive to amyloid-induced damage

This study examines lipid composition and amyloid beta interactions in naked mole-rat brain membranes, finding they are cholesterol-rich, highly phase-separated, and more susceptible to amyloid-induced damage compared to mouse membranes.

Hepatocyte-specific deletion of Pparα promotes NASH in the context of obesity

This study shows that deleting Ppar in hepatocytes promotes NASH in obese mice without glucose intolerance, highlighting the role of extra-hepatocyte PPAR in metabolic responses to HFD.