Constitutive signaling by the C-terminal fragment of polycystin-1 is mediated by a tethered peptide agonist
B. S. Magenheimer, E. Nevarez Munoz, J. Ravichandran, R. L. Maser
This paper shows that the C-terminal fragment of polycystin-1 mediates signaling via a tethered peptide agonist mechanism, and that mutations in the stalk region affect this process.
bioRxiv · Aug 20, 2021 · PreprintBiochemistry