B. S. Magenheimer

This study identifies stalk-derived peptides that activate PC1 signaling by binding to specific regions, revealing structural dynamics and potential therapeutic applications for ADPKD.

This paper shows that the C-terminal fragment of polycystin-1 mediates signaling via a tethered peptide agonist mechanism, and that mutations in the stalk region affect this process.

This paper investigates the mechanism of tethered agonist-mediated signaling in PC1 CTF using simulations and experiments, revealing an allosteric pathway involving specific residue interactions.

This study shows that H2-GMZ reduces cyst formation in ADPKD by inhibiting Cl- secretion, cell proliferation, and motility in both in vitro and in vivo models.