Author

R. L. Maser

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:deep learning· 2 Assay:proteomics· 2 Approach:statistical model· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. S. Magenheimer· 3 shared E. Nevarez-Munoz· 2 shared S. Pawnikar· 2 shared Y. Miao· 2 shared A. Haldane· 1 shared E. Nevarez Munoz· 1 shared J. Ravichandran· 1 shared K. Joshi· 1 shared

Activity by Year

2021-2024 · peak 2/yr

Co-Author Collaboration Network

8 top collaborators · 18 mutual co-author links

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3 shared papersBiochemistry

B. S. Magenheimer

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Author profile →

3 papers

Recent·Most cited

Activation of Polycystin-1 Signaling by Binding of Stalk-derived Peptide Agonists

S. Pawnikar, B. S. Magenheimer, K. Joshi, E. Nevarez-Munoz, A. Haldane, R. L. Maser, Y. Miao

This study identifies stalk-derived peptides that activate PC1 signaling by binding to specific regions, revealing structural dynamics and potential therapeutic applications for ADPKD.

bioRxiv · Jan 6, 2024Biochemistry

Constitutive signaling by the C-terminal fragment of polycystin-1 is mediated by a tethered peptide agonist

B. S. Magenheimer, E. Nevarez Munoz, J. Ravichandran, R. L. Maser

This paper shows that the C-terminal fragment of polycystin-1 mediates signaling via a tethered peptide agonist mechanism, and that mutations in the stalk region affect this process.

bioRxiv · Aug 20, 2021 · PreprintBiochemistry

Mechanism of Tethered Agonist-Mediated Signaling by Polycystin-1

S. Pawnikar, B. S. Magenheimer, E. Nevarez-Munoz, R. L. Maser, Y. Miao

This paper investigates the mechanism of tethered agonist-mediated signaling in PC1 CTF using simulations and experiments, revealing an allosteric pathway involving specific residue interactions.

bioRxiv · Aug 5, 2021Biochemistry