Transcriptome profiling of human pluripotent stem cell-derived cerebellar organoids reveals fastercommitment under dynamic conditions
T. P. Silva, R. Sousa-Luis, T. G. Fernandes, E. P. Bekman, C. A. V. Rodrigues, S. H. Vaz, L. M. Moreira, Y. Hashimura, S. Jung, B. Lee, M. Carmo-Fonseca, J. M. S. Cabral
This study shows that dynamic differentiation using Vertical-Wheel bioreactors produces cerebellar organoids with faster commitment and enriched extracellular matrix, improving their neural microenvironment and functional maturation.
bioRxiv · Jan 27, 2021Bioengineering