S. Jung

Competitive fungal commensalism mitigates candidiasis pathology

This study identifies a fungal commensal that competes with Candida albicans to reduce its burden and mitigate candidiasis in mice.

Synthesis and Biological Assessment of Chalcone and Pyrazoline Derivatives as novel inhibitor for ELF3-MED23 Interaction

This study synthesizes and evaluates chalcone and pyrazoline derivatives as ELF3-MED23 PPI inhibitors, showing compound 10 effectively reduces HER2 levels and induces apoptosis in HER2-positive gastric cancer cells.

Streptococcal meningoencephalitis dynamically shapes developmental monocyte and macrophage trajectories in the CNS

This study shows that streptococcal meningoencephalitis alters monocyte and macrophage dynamics in the dura by shifting their origin from skull bone marrow to peripheral sources and increasing MDP-Mo-derived cells.

Glyoxalase 1: emerging biomarker and therapeutic target in cervical cancer progression

This study identifies Glyoxalase-1 (GLO1) as significantly upregulated in cervical cancer tissues and shows its role in cancer metabolism, suggesting it as a potential biomarker and therapeutic target.

The actomyosin system is essential for the integrity of the endosomal system in bloodstream form Trypanosoma brucei

This study investigates the role of the actomyosin system in maintaining endosomal integrity in Trypanosoma brucei using imaging and biochemical assays.

Monocyte-derived microglia with Dnmt3a mutation cause motor pathology in aging mice

This study shows that monocyte-derived microglia with a Dnmt3a mutation cause motor deficits in aging mice, resembling Parkinsonian disorders.

Convergent evolution of monocyte differentiation in adult skin instructs Langerhans cell identity

The paper investigates how monocyte differentiation in adult skin leads to Langerhans cell identity through intrinsic and extrinsic factors.

Smart Slides for Optical Monitoring of Cellular Processes

The paper develops Smart Slides, a nanosensor-coated platform for optically monitoring dopamine release from neuronal cells in response to psychotropic substances.

Murine GMP- and MDP-derived classical monocytes have distinct functions and fates

This study identifies distinct functions and fates of murine classical monocytes derived from GMP and MDP, showing differential contributions to tissue macrophage populations.

Mice with renal-specific alterations of stem cell-associated signaling develop symptoms of chronic kidney disease but surprisingly no tumors

The paper generates kidney organoids and genetic mouse models with altered stem cell signaling, finding CKD symptoms but no tumors.

MHC class II-restricted antigen presentation is required to prevent dysfunction of cytotoxic T cells by blood-borne myeloids in brain tumors

This study shows that MHC class II antigen presentation on blood-borne myeloids is essential to maintain functional CD8+ T cells in brain tumors by preventing Tox-driven dysfunction.

Absence of the bile acid enzyme CYP8B1 increases brain chenodeoxycholic acid and reduces neuronal excitotoxicity in mice

This study shows that absence of CYP8B1 increases brain chenodeoxycholic acid (CDCA) levels, reducing neuronal excitotoxicity and stroke infarct area in mice.

Enteric glial cells favour accumulation of anti-inflammatory macrophages during the resolution of muscularis inflammation

This study identifies how enteric glial cells promote the differentiation of anti-inflammatory macrophages during muscularis inflammation resolution through CCL2 and CSF1 signaling.

LRBA balances antigen presentation and T-cell responses via autophagy through the binding to PIK3R4 and FYCO1

This study identifies LRBA's role in balancing antigen presentation and T-cell responses by interacting with PIK3R4 and FYCO1 to regulate autophagy.

A small-molecule myosin inhibitor as a targeted multi-stage antimalarial

This paper develops a small-molecule myosin inhibitor, KNX-115, effective against multiple stages of Plasmodium infection with high selectivity and potency.

Maternal provisioning of an obligate symbiont

The paper investigates vertical transmission of an obligate symbiont in a viviparous sponge, finding that symbiont provision varies with reproductive output and offspring size, challenging previous assumptions based on oviparous species.

MAPK13 stabilization via m6A modification limits anti-cancer efficacy of rapamycin

This study shows that m6A modification of MAPK13 mRNA by the METTL3-METTL14-WTAP complex promotes its degradation, and rapamycin stabilizes MAPK13, which enhances anti-cancer effects when silenced.

FMRP-Regulated Alternative Splicing is Multifactorial and Resembles Splicing Control by MBNL1

This study shows that FMRP deficiency leads to altered splicing via Mbnl1 auto-splicing and redistribution of MBNL1 isoforms, affecting splicing in multiple RNAs.

Characterisation of TbSmee1 indicates that endocytosis is required for access of surface-bound cargo to the trypanosome flagellar pocket

This study characterizes TbSmee1 in Trypanosoma brucei, showing that endocytosis is required for surface-bound cargo to access the flagellar pocket.

Tongue immune compartment analysis reveals spatial macrophage heterogeneity

This study identifies two distinct macrophage subsets in the murine tongue using single-cell RNA-sequencing and in situ immunophenotyping, revealing their spatial distribution and differential responses to systemic LPS.

Production of novel Spike truncations in Chinese hamster ovary cells

The paper improves Spike protein expression in CHO cells by developing truncations that outperform full-length Spike and RBD in expression levels and antibody binding.

A distinct CD115- erythro-myeloid precursor present at the maternal-embryonic interface and in the bone marrow of adult mice

The paper identifies a CD115- macrophage precursor in adult bone marrow that shares features with embryonic erythro-myeloid progenitors and is present at the maternal-embryonic interface.

Structure and lipid-mediated remodelling mechanism of the Na+/H+ exchanger NHA2

This paper reports the cryo-EM structures of NHA2 and reveals its lipid-mediated dimerization mechanism for ion exchange.

SARS-Cov-2 Spike binding to ACE2 is stronger and longer ranged due to glycan interaction

The paper uses molecular dynamics simulations to show that glycosylation enhances the binding strength and range of SARS-CoV-2 Spike to ACE2 through glycan-mediated interactions.

Transcriptome profiling of human pluripotent stem cell-derived cerebellar organoids reveals fastercommitment under dynamic conditions

This study shows that dynamic differentiation using Vertical-Wheel bioreactors produces cerebellar organoids with faster commitment and enriched extracellular matrix, improving their neural microenvironment and functional maturation.

Homogenization of a Reaction Diffusion Equation can Explain Influenza A Virus Load Data

The paper uses a reaction diffusion model to explain how spatial heterogeneity in MEF affects influenza A virus load, showing that homogenization explains observed inhomogeneities.

Ribonucleotide reductase, a novel target for gonorrhea

This study identifies two novel inhibitors of Neisseria gonorrhoeae that target ribonucleotide reductase, showing efficacy against multidrug-resistant strains in a mouse model.

Plant NLR targets P-type ATPase for executing plasma membrane depolarization leading to calcium influx and cell death

The paper shows that the plant NLR CCA309 targets P-type ATPase to cause membrane depolarization, calcium influx, and cell death during hypersensitive response.

Defining Monocyte Differentiation into Colonic and Ileal Macrophages

This study identifies factors and gene expression signatures involved in monocyte differentiation into colon and ileum-resident macrophages under non-inflammatory conditions.

6-O-galloylsalidroside, an active ingredient from Acer tegmentosum, ameliorates alcoholic steatosis and liver injury in a mouse model of chronic ethanol consumption

This study investigates the effect of 6-O-galloylsalidroside on alcoholic steatosis and liver injury in mice, finding it reduces lipid accumulation and liver damage.