RORc expressing immune cells negatively regulate tertiary lymphoid structure formation and support their pro-tumorigenic functions
E. Cinnamon, I. Stein, E. Zino, S. Rabinovich, Y. Shovman, Y. Schlesinger, T. M. Salame, S. Reich-Zeliger, M. Lotem, Y. Ben-Neriah, O. Parnas, E. Pikarsky
This study shows RORc-expressing immune cells suppress tertiary lymphoid structure (TLS) formation in liver cancer, leading to pro-tumorigenic TLSs, while their absence results in anti-tumorigenic TLSs.
bioRxiv · Jul 2, 2022Cancer Biology