Author

T. M. Salame

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Agrawal· 1 shared A. Harmelin· 1 shared A. Kimchi· 1 shared A. Mayo· 1 shared A. Tuval· 1 shared D. Leshkowitz· 1 shared E. Cinnamon· 1 shared E. Hagai· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 6 mutual co-author links

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1 shared paperCell Biology

A. Agrawal

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

p16-dependent upregulation of PD-L1 impairs immunosurveillance of senescent cells

J. Majewska, A. Agrawal, A. Mayo, L. Roitman, R. Chatterjee, J. Kralova, T. Landsberger, Y. Katzenelenbogen, T. M. Salame, E. Hagai, N. Stanojevic, I. Amit, U. Alon, V. Krizhanovsky

This study identifies p16-dependent upregulation of PD-L1 in senescent cells as a mechanism to evade immune clearance, showing that anti-PD-L1 treatment can eliminate these cells.

bioRxiv · Jan 30, 2023 · PreprintCell Biology

RORc expressing immune cells negatively regulate tertiary lymphoid structure formation and support their pro-tumorigenic functions

E. Cinnamon, I. Stein, E. Zino, S. Rabinovich, Y. Shovman, Y. Schlesinger, T. M. Salame, S. Reich-Zeliger, M. Lotem, Y. Ben-Neriah, O. Parnas, E. Pikarsky

This study shows RORc-expressing immune cells suppress tertiary lymphoid structure (TLS) formation in liver cancer, leading to pro-tumorigenic TLSs, while their absence results in anti-tumorigenic TLSs.

bioRxiv · Jul 2, 2022Cancer Biology

Single-cell epigenetic analysis reveals principles of chromatin states in H3.3-K27M gliomas

N. Harpaz, T. Mittelman, O. Beresh, O. Griess, N. Furth, T. M. Salame, R. Oren, L. Fellus-Alyagor, A. Harmelin, S. Alexandrescu, J. G. Marques, M. G. Filbin, G. Ron, E. Shema

The paper uses CyTOF to analyze histone modifications in DIPG tumors, identifying two epigenetically distinct subpopulations with differential proliferation and marker expression.

bioRxiv · Nov 2, 2021Cancer Biology

Pseudo-mutant p53 as a targetable phenotype of DNMT3A-mutated pre-leukemia

A. Tuval, Y. Brilon, H. Ezogy, Y. Moskovitz, T. Biezuner, D. Leshkowitz, T. M. Salame, M. D. Minden, P. Tal, V. Rotter, M. Oren, N. Kaushansky, L. I. Shlush

The paper identifies a pseudomutant p53 conformation in DNMT3A-mutated pre-leukemic HSPCs and shows that shifting to the wild-type conformation can eliminate these cells.

bioRxiv · May 30, 2021 · PreprintCancer Biology

A functional pre-screening platform for identifying points of vulnerability in the cell death map of human melanoma tumors

N. P. Dekel-Bird, S. Bialik, O. Itzhaki, T. M. Salame, N. Yaeli-Slonim, V. Levin-Salomon, S. K. Dasari, M. Besser, A. Kimchi

The paper develops a prescreening platform to identify tumor-specific vulnerabilities in melanoma cell death networks, improving targeted therapy by reducing drug resistance and relapse.

bioRxiv · Nov 11, 2020Cancer Biology

CSNAP, the smallest CSN subunit, modulates proteostasis through cullin-RING ubiquitin ligases

M. G. Füzesi-Levi, R. I. Enchev, G. Ben-Nissan, Y. Levin, M. Kupervaser, G. Friedlander, T. M. Salame, R. Nevo, M. Peter, M. Sharon

This study identifies CSNAP as a key subunit of the CSN complex that modulates CRL activity through steric inhibition, affecting cell viability and DNA damage response.

bioRxiv · Oct 2, 2018Biochemistry