Intermittent fasting induces rapid hepatocyte proliferation to restore the hepatostat in the mouse liver.
A. Sarkar, Y. Jin, B. C. DeFelice, C. Y. Logan, Y. Yang, T. Anbarchian, P. Wu, M. Morri, N. Neff, H. Nguyen, E. Rulifson, M. Fish, A. M. Martinez Jaimes, R. Nusse
This study shows intermittent fasting induces rapid hepatocyte proliferation in mice to maintain liver-to-body-mass ratio, challenging the view that liver tissue is quiescent unless injured.
bioRxiv · Oct 16, 2021Cell Biology