The protein-bound uremic solute 3-carboxy-4-methyl-5-propyl-2-furanpropionate (CMPF) increases erythrocyte osmotic fragility through interaction with the mechanosensitive channel Piezo1.
B. A. Kondo Van Spitzenbergen, G. Bohnen, E. S. Dias, J. B. Monte Alegre, G. F. Dias, N. Grobe, A. N. Moreno-Amaral, P. Kotanko
The paper shows CMPF increases erythrocyte osmotic fragility by activating Piezo1, similar to Jedi1, and this effect is blocked by the Piezo1 inhibitor GsMTx-4.
bioRxiv · May 26, 2023 · PreprintCell Biology