Charting the transcriptomic landscape of primary and metastatic cancers in relation to their origin and target normal tissues
N. Sanghvi, C. Calvo-Alcaniz, P. Rajagopal, S. Scalera, V. Canu, S. Sinha, F. Schischlik, K. Wang, S. Madan, E. Shulman, A. Papanicolau-Sengos, G. Blandino, E. Ruppin, N. Nair
The paper compares gene expression in primary and metastatic tumors to their origin and target tissues, finding metastases more resemble target tissues and show reduced cancer hallmark activity.
bioRxiv · Oct 30, 2023Cancer Biology