Author

F. Schischlik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Cell Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 5 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:genetic perturbation / CRISPR· 2 Assay:scRNA-seq· 2 Approach:statistical model· 2

Frequent Co-Authors

E. Ruppin· 3 shared A. A. Schäffer· 1 shared A. Brown· 1 shared A. C. Mueller· 1 shared A. Cesar-Razquin· 1 shared A. Deshpande· 1 shared A. Fauster· 1 shared A. J. Deshpande· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 13 mutual co-author links

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3 shared papersCancer Biology

E. Ruppin

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Charting the transcriptomic landscape of primary and metastatic cancers in relation to their origin and target normal tissues

N. Sanghvi, C. Calvo-Alcaniz, P. Rajagopal, S. Scalera, V. Canu, S. Sinha, F. Schischlik, K. Wang, S. Madan, E. Shulman, A. Papanicolau-Sengos, G. Blandino, E. Ruppin, N. Nair

The paper compares gene expression in primary and metastatic tumors to their origin and target tissues, finding metastases more resemble target tissues and show reduced cancer hallmark activity.

bioRxiv · Oct 30, 2023Cancer Biology

High Density Domain-Focused CRISPR Screens Reveal Novel Epigenetic Regulators of HOX/MEIS Activation in Acute Myeloid Leukemia

K. Barbosa, A. Deshpande, M. E. Perales, P. Xiang, R. Murad, A. Minkina, N. A. Robertson, F. Schischlik, X. Lei, Y. Sun, A. Brown, D. Amend, I. Jeremias, J. G. Doench, K. Humphries, , A. J. Deshpande

The paper identifies SGF29 as a novel chromatin regulator of MEIS1 and AML oncogenes, showing its role in leukemogenesis and potential as a drug target.

bioRxiv · Dec 12, 2022 · PreprintCancer Biology

scRNA-seq analysis of colon and esophageal tumors uncovers abundant microbial reads in myeloid cells undergoing proinflammatory transcriptional alterations

W. Robinson, J. K. Stone, F. Schischlik, B. Gasmi, M. C. Kelly, C. Seibert, K. Dadkhah, E. M. Gertz, J. S. Lee, K. Zhu, L. Ma, X. W. Wang, C. Sahinalp, R. Patro, M. D. Leiserson, , E. Ruppin

The paper develops a computational pipeline to identify microbial reads in scRNA-seq data and finds that microbial reads are enriched in myeloid cells with proinflammatory transcriptional changes.

bioRxiv · May 14, 2020 · PreprintCancer Biology

MTHFD1 is a genetic interactor of BRD4 and links folate metabolism to transcriptional regulation

S. Sdelci, A. Rendeiro, P. Rathert, G. Hofstaetter, A. Ringler, H. P. Moll, W. You, K. Klavins, B. Guertl, M. Farlik, S. Schick, F. Klepsch, M. Oldach, P. Buphamalai, F. Schischlik, , S. Kubicek

This study identifies MTHFD1 as a genetic and physical interactor of BRD4, linking folate metabolism to transcriptional regulation and showing synergistic effects on cancer cell viability.

bioRxiv · Oct 10, 2018Cancer Biology

Systematic genetic mapping of necroptosis identifies SLC39A7 as modulator of death receptor trafficking

A. Fauster, M. Rebsamen, K. L. Willmann, A. Cesar-Razquin, E. Girardi, J. W. Bigenzahn, F. Schischlik, S. Scorzoni, M. Bruckner, J. Konecka, K. Hörmann, L. X. Heinz, K. Boztug, G. Superti-Furga

The paper uses genetic screens to identify SLC39A7 as a modulator of necroptosis by affecting TNF receptor trafficking and ER homeostasis.

bioRxiv · Mar 29, 2018Cell Biology